Abstract
SARS-CoV-2 has created tremendous chaos in the world due to infections caused by it that affected the human cells. Its glycoprotein receptors have greater contribution in attaching the viral particle to Receptor Binding Domain (RBD) of host cells. In this review, the effect of temperature on SARS-COV 2 spike glycoproteins and their binding molecular interactions and behaviors have been analyzed and found that temperature affects the mechanism of virus-host cell interactions.